Reviewed by: Dr. Priyadatt Patel, Senior Gynecologist · Advanced Laparoscopic Surgeon · IVF and Endometriosis Programme Lead. Last updated: 26 May 2026.
Advanced ART · PGT
Pre-implantation Genetic Testing (PGT-A, PGT-M, PGT-SR)
Pre-implantation genetic testing analyses embryo biopsies for chromosomal or specific genetic abnormalities before transfer. It selects euploid embryos and can prevent transmission of known genetic disorders.
Types of PGT
PGT-A, PGT-M, PGT-SR explained
PGT-A (aneuploidy) screens for whole-chromosome errors that cause failed implantation or miscarriage.
PGT-M (monogenic) tests for specific inherited single-gene disorders when a parent is a known carrier.
PGT-SR (structural rearrangement) detects unbalanced translocations in couples with known balanced rearrangements.
When PGT may help
Patient selection
- Advanced maternal age (≥38) with elevated aneuploidy risk
- Recurrent pregnancy loss with documented aneuploid losses
- Recurrent IVF implantation failure
- Known parental balanced translocation
- Known inherited genetic condition with family history
Limitations
What PGT cannot do
PGT-A reduces miscarriage rates and time to live birth in older women but does not increase cumulative live birth rates in all populations. Biopsy carries small risk of embryo damage. Mosaicism complicates results in 15-20 percent of biopsies.
Common questions
Frequently asked
Does PGT-A guarantee a healthy baby?
No. PGT-A reduces miscarriage risk by transferring euploid embryos but does not screen for all genetic conditions or congenital anomalies.
When does PGT clearly improve outcomes?
Recurrent miscarriage with documented aneuploidy, recurrent implantation failure, advanced maternal age, and known parental genetic conditions are the clearest indications.
Can a mosaic embryo be transferred?
Increasingly yes, with appropriate counselling. Outcome data from mosaic transfers continues to evolve. We discuss the specific mosaic level and chromosomes involved before decision-making.
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Dr. Priyadatt Patel
Senior Gynecologist · Advanced Laparoscopic Surgeon · IVF and Endometriosis Programme Lead
MS OBGyn · Pregnancy Care · Advanced Gynaecological Ultrasound · Fertility Preservation
ESHRE / ESGE / AAGL / ASRM guideline-aligned practice. 3D Karl Storz precision technique. Fertility-preservation-first philosophy. Evidence-based decisions, honest counselling, long-term outcomes orientation.
Endometriosis
Superficial to deep infiltrating, fertility-preserving excision
IVF & Fertility
Individualised protocols, ART Level 2 lab, transparent outcomes
Advanced Laparoscopy
3D Karl Storz precision, nerve-sparing technique
Pregnancy Care
Antenatal care, high-risk pregnancy, advanced ultrasound
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