Reviewed by: Dr. Priyadatt Patel, Senior Gynecologist · Advanced Laparoscopic Surgeon · IVF and Endometriosis Programme Lead. Last updated: 26 May 2026.
Fetal Medicine · CVS
Chorionic Villus Sampling (CVS)
First-trimester invasive diagnostic test providing definitive chromosomal and genetic diagnosis from 11-13 weeks of pregnancy.
Procedure
How CVS is performed
A fine needle is inserted through the maternal abdomen under continuous ultrasound guidance to sample chorionic villi (placental tissue) which share fetal genetic material. Procedure takes 5-10 minutes.
Indications
When CVS is offered
- High-risk NT combined screening
- Abnormal NIPT result requiring confirmation
- Known parental balanced chromosomal rearrangement
- Single-gene disorder testing where parents are carriers
- Specific structural fetal abnormality on first-trimester ultrasound
Aftercare and results
What to expect
Rest for 24 hours. Mild cramping is normal. Rapid PCR/FISH results in 2-3 days; full karyotype in 10-14 days.
Common questions
Frequently asked
What is the difference between CVS and amniocentesis?
CVS samples placenta and is done earlier (11-13 weeks). Amniocentesis samples amniotic fluid and is done from 16 weeks. CVS allows earlier decisions.
Is CVS safer than amniocentesis?
Both procedures have similar safety in experienced hands – miscarriage risk under 0.5 percent. CVS provides earlier diagnosis.
Can CVS detect all genetic problems?
CVS detects chromosomal abnormalities and specific gene mutations when tested for. It does not screen for all possible genetic conditions or structural abnormalities.
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Dr. Priyadatt Patel
Senior Gynecologist · Advanced Laparoscopic Surgeon · IVF and Endometriosis Programme Lead
MS OBGyn · Pregnancy Care · Advanced Gynaecological Ultrasound · Fertility Preservation
ESHRE / ESGE / AAGL / ASRM guideline-aligned practice. 3D Karl Storz precision technique. Fertility-preservation-first philosophy. Evidence-based decisions, honest counselling, long-term outcomes orientation.
Endometriosis
Superficial to deep infiltrating, fertility-preserving excision
IVF & Fertility
Individualised protocols, ART Level 2 lab, transparent outcomes
Advanced Laparoscopy
3D Karl Storz precision, nerve-sparing technique
Pregnancy Care
Antenatal care, high-risk pregnancy, advanced ultrasound
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